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- The most common side effect experienced by people taking linaclotide or plecanatide is diarrhea.
- Both improve abdominal and stool symptoms within the first week however, their maximum effect on pain can take longer to appear. Both drugs treat overall IBS-C symptoms and are FDA approved for the treatment of IBS-C and CIC. Both have also been shown to reduce abdominal pain by decreasing activity of pain sensing nerves.
- Linaclotide (Linzess®) and Plecanatide (Trulance®) work by increasing fluid secretion and gut movement.
- Lubiprostone is also FDA approved for the treatment of chronic idiopathic constipation (CIC) and opioid induced constipation (OIC) for people with chronic non-cancer pain related illnesses.
- Common adverse events include nausea and diarrhea.
- This drug has proven to be effective in men as well. This is due to the limited numbers of men that were enrolled in the initial trials.
- It is currently FDA approved specifically for use in women.
- While the direct mechanism of pain relief is not known, lubiprostone has been proven to relieve overall IBS symptoms in multiple trials. This leads to increased bowel movement frequency.
- Lubiprostone (Amitiza®) works through the activation of chloride channels in the bowel.
- Currently there are 3 FDA approved treatments in this class: lubiprostone, linaclotide, plecanatide, These drugs also can improve pain, discomfort, and bloating. Secretagogues/Prosecretory agents are a class of drugs which increase fluid secretion and movement in the GI tract.
- IBS Patients: Their Illness Experience and Unmet Needs.
- Irritable Bowel Syndrome and a Healthy Holiday Season.
- Assessing the Risk and Benefit in Treatment.
- Relaxation Techniques to Manage IBS Symptoms.
- Complementary and Alternative Medicine: Selecting a Practitioner.
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- Complementary and Alternative Treatments.
- Understanding and Managing Pain in Irritable Bowel Syndrome (IBS).
- Five Low FODMAP Diet Pitfalls (and What You Can Do to Avoid Them).
- The Low FODMAP Diet Approach: Dietary Triggers for IBS Symptoms.
- Changes You Should Not Ignore if You Have IBS.
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